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Proposed mechanism for the roles of ONOO – and U NO on PGHS-1 activity.

Proposed mechanism for the roles of ONOO – and U NO on PGHS-1 activity.

Download scientific diagram | Proposed mechanism for the roles of ONOO – and U NO on PGHS-1 activity. Peroxynitrite-derived radicals inactivate PGHS-1. In parallel, U NO 2 causes both   from publication: Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: A free radical mechanism of inactivation | Peroxynitrite (ONOO(-)) can serve either as a peroxide substrate or as an inactivator of prostaglandin endoperoxide H synthase-1 (PGHS-1). Herein, the mechanism of PGHS-1 inactivation by ONOO(-) and the modulatory role that nitric oxide (*NO) plays in this process were | Free Radicals, Nitric Oxide and Prostaglandin-Endoperoxide Synthases | ResearchGate, the professional network for scientists.

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